Elucidating a Myofibroblast-dominated Fibrotic Niche in Crohn’s Disease-associated Fibrostenosis Through High-resolution Spatial Transcriptomics
This case-level, high-resolution spatial analysis delineates a spatially organized fibrotic niche within a CD stricture, composed of distinct stromal and immune populations. We define the identity and origins of profibrotic myofibroblasts and characterize pericyte-to-myofibroblast reprogramming, thereby highlighting specific cell subtypes as prime therapeutic targets for antifibrotic strategies.
Authors
- Fang Xie (ORCID: https://orcid.org/0000-0002-3429-4647)
- Fangting Wu (ORCID: https://orcid.org/0009-0009-2789-9216)
- Hui Yang
- X.L. Zou (ORCID: https://orcid.org/0009-0004-4103-0422)
- Kai Sun (ORCID: https://orcid.org/0000-0002-2533-5937)
- Shengnan Sun (ORCID: https://orcid.org/0009-0007-6764-5750)
- Lan Bai (ORCID: https://orcid.org/0000-0002-4397-5153)
- Jufang Shi (ORCID: https://orcid.org/0000-0001-5283-9762)
- David Zhang (ORCID: https://orcid.org/0000-0002-2983-9796)
- J. Li (ORCID: https://orcid.org/0000-0001-5245-2074)
- Anqi Yu
- Xiaoxia Lin (ORCID: https://orcid.org/0009-0003-7698-8748)
- Jintao Shi
- Mengjia He
- Wenting Xie
- Ting Ouyang
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101701
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00