Enhanced lysosomal glycogen breakdown is associated with liver tumorigenesis in glycogen storage disease type III
This study provides novel insights into the metabolic dysregulations driving liver tumorigenesis in glycogen storage disease type III (GSDIII). Our findings reveal a potential link between abnormal glycogen accumulation and liver cancer, highlighting the pivotal role of lysosomal glycogen degradation in supporting tumor growth. These results are particularly important for researchers and clinicians working on metabolic liver diseases, as they suggest potential glycogen-targeting therapeutic strategies for GSDIII and other related liver disorders. Practically, they could guide future interventions aimed at modulating glycogen metabolism, offering new treatment avenues for patients with GSDIII at risk of hepatocellular carcinoma, while contributing to the broader understanding of metabolic dysregulation in cancer biology.
Authors
- Edoardo Malfatti (ORCID: https://orcid.org/0000-0001-7871-8600)
- Louisa Jauze (ORCID: https://orcid.org/0000-0002-9474-6377)
- Emilie Bertil-Froidevaux
- Jérémie Cosette
- Christophe Georger
- Simon Gay (ORCID: https://orcid.org/0009-0007-8221-8861)
- Laetitia van Wittenberghe
- Charlotte Mussini (ORCID: https://orcid.org/0009-0004-7759-2929)
- Gilles Mithieux (ORCID: https://orcid.org/0000-0003-3579-8529)
- Christophe Tatout (ORCID: https://orcid.org/0000-0001-5215-2338)
- Araceli Aguilar-González (ORCID: https://orcid.org/0000-0002-2960-8672)
- Fabienne Rajas (ORCID: https://orcid.org/0000-0002-9233-7633)
- Giuseppe Ronzitti (ORCID: https://orcid.org/0000-0002-9184-0210)
- Valle Montalvo-Romeral (ORCID: https://orcid.org/0000-0001-7183-3710)
- Valérie Paradis (ORCID: https://orcid.org/0000-0003-3142-3762)
- Antoine Gardin (ORCID: https://orcid.org/0000-0002-1770-4368)
- F. Maillot
- Alicia Mayeuf-Louchart (ORCID: https://orcid.org/0000-0002-3787-7450)
- Fanny Bordier
- Amandine Gautier‐Stein (ORCID: https://orcid.org/0000-0002-6003-1891)
- Fanny Dujardin (ORCID: https://orcid.org/0000-0001-7709-9844)
- M. Amaouche (ORCID: https://orcid.org/0000-0001-7829-9549)
- Félicie Evrard
- Gwendoline Perrot (ORCID: https://orcid.org/0009-0002-0623-6199)
- Alicia Leblond
- Philippe Labrune
- Carine Zitoun-Ardon
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Université de Tours (FR)
- Délégation Paris 5 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Université Paris-Saclay (FR)
- Hôpital Beaujon (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Paris Cité (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Recherche Jean Pierre Aubert (FR)
- Clinical Investigation Center Plurithematic Tours (FR)
- University of Clermont Auvergne (FR)
- Genethon (France) (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Clermont Université (FR)
- Hôpital Antoine-Béclère (FR)
- Institut Mondor de Recherche Biomédicale (FR)
- Bicêtre Hospital (FR)
- Université d'Évry Val-d'Essonne (FR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101702
- Primary Topic
- Glycogen Storage Diseases and Myoclonus
- Type
- article
- Field-Weighted Citation Impact
- 0.00