GPX8 is transcriptionally regulated by KLF16 and promotes osteosarcoma progression
This study demonstrated that GPX8 is a critical oncogene in OS progression and that its expression is regulated by KLF16. Targeting the KLF16/GPX8 axis may offer promising prospects for the development of novel therapeutic strategies against OS.
Authors
- Cairong Dong
- Zhizeng Gao (ORCID: https://orcid.org/0000-0002-8176-0727)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-2357-7940)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12967-025-07313-5
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China