Factors Associated with Time to Viral Load Suppression Among People Living with HIV in Chingola District: A Retrospective Cohort Study

Improving health outcomes and lowering human immunodeficiency virus (HIV) transmission among people living with human immunodeficiency virus (PLHIV) requires achieving viral load suppression. In this study, people living with HIV in Zambia's Chingola District had their survival rates and factors related to viral suppression assessed. The research aimed at analysing factors associated with time to viral suppression among PLHIV in Chingola District using survival analysis. A retrospective cohort study design was used, utilising 385 clinical records of PLHIV in Chingola district, with the focus on 15 months period (January 2022 to April 2023). Cox proportional hazards regression models and Kaplan-Meier survival analysis were used as statistical techniques. The age group 50+ years accounted the highest proportion (45.5%), while 40–49 age group accounted for the least proportion (15.3%). Males dominated (56.6%) whereas 43.4% were females. The median time to attain viral suppression was 12 months. Consequently, frequent clinic visits significantly decreased suppression time (aHR = 2.026, <i>p</i> = 0.001), and PLHIV with comorbidity experienced faster viral suppression (aHR = 1.438, <i>p</i> = 0.017). None substance users had 1.392 times increased chances of achieving Viral load suppression higher than substance users (aHR = 1.392, <i>p</i> = 0.036). The intervention that increased the chance of suppression was case conferencing (aHR = 7.309, <i>p</i> = 0.001). The results highlighted how crucial it is to design interventions specifically for high-risk groups to enhance viral load results. Suggestions include implementing focused interventions for PLHIV with comorbidities and substance abusers, expanding case conferences, and fortifying adherence support networks.

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Journal
World Journal of Public Health
Published
2025-11-14
DOI
https://doi.org/10.11648/j.wjph.20251004.19
Primary Topic
HIV/AIDS Research and Interventions
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article
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article

Factors Associated with Time to Viral Load Suppression Among People Living with HIV in Chingola District: A Retrospective Cohort Study

Kelvin Mwangilwa, Moses Mbewe, Eustarckio Kazonga, Moses Mwale et al.
World Journal of Public Health
HIV/AIDS Research and Interventions
article

Factors Associated with Time to Viral Load Suppression Among People Living with HIV in Chingola District: A Retrospective Cohort Study

Kelvin Mwangilwa, Moses Mbewe, Eustarckio Kazonga, Moses Mwale, Innocent Mwaba, Lackeby Kawanga, Adrian Phiri, Tyson Chipokoso, Norah Ndambo, Thanthwe Mangani, Bryson Musonda, Hiwena Malawo, Sandra Diana Mwadetsa, Paul Kasinde, Rabson Kanyinji
article en

Abstract

Improving health outcomes and lowering human immunodeficiency virus (HIV) transmission among people living with human immunodeficiency virus (PLHIV) requires achieving viral load suppression. In this study, people living with HIV in Zambia's Chingola District had their survival rates and factors related to viral suppression assessed. The research aimed at analysing factors associated with time to viral suppression among PLHIV in Chingola District using survival analysis. A retrospective cohort study design was used, utilising 385 clinical records of PLHIV in Chingola district, with the focus on 15 months period (January 2022 to April 2023). Cox proportional hazards regression models and Kaplan-Meier survival analysis were used as statistical techniques. The age group 50+ years accounted the highest proportion (45.5%), while 40–49 age group accounted for the least proportion (15.3%). Males dominated (56.6%) whereas 43.4% were females. The median time to attain viral suppression was 12 months. Consequently, frequent clinic visits significantly decreased suppression time (aHR = 2.026, <i>p</i> = 0.001), and PLHIV with comorbidity experienced faster viral suppression (aHR = 1.438, <i>p</i> = 0.017). None substance users had 1.392 times increased chances of achieving Viral load suppression higher than substance users (aHR = 1.392, <i>p</i> = 0.036). The intervention that increased the chance of suppression was case conferencing (aHR = 7.309, <i>p</i> = 0.001). The results highlighted how crucial it is to design interventions specifically for high-risk groups to enhance viral load results. Suggestions include implementing focused interventions for PLHIV with comorbidities and substance abusers, expanding case conferences, and fortifying adherence support networks.

World Journal of Public HealthVol. 10(4)
Ministry of Health (ZM), University of Lusaka (ZM), World Health Organization - Zambia (ZM), National Institute of Public Administration (ZM)
Openalex Percentile: Top 56%
HIV/AIDS Research and Interventions
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