Investigation of the Impact of Peri‐Implantitis Processes on Interleukin Profiles in Peri‐Implant Crevicular Fluid

The present study demonstrated that IL-1α, IL-6, and IL-10 levels in PICF are closely associated with the severity of peri-implant inflammation. Among these cytokines, IL-10 showed the strongest relationship with BOP, indicating its important role in the modulation of local immune activity. IL-6 was also positively correlated with inflammatory severity, reflecting its involvement in sustaining the destructive processes within peri-implant tissues. Overall, the obtained data suggest that IL-6 and IL-10 may serve as useful indicators of ongoing inflammatory activity in peri-implantitis. However, their prognostic or diagnostic utility requires confirmation in longitudinal studies assessing temporal cytokine changes and treatment outcomes.