CCR5 expression and conformational stability as potential cooperative modulators of immune phenotypes and therapy response in breast cancer
Our study supports a dual regulatory hypothesis, in which CCR5 expression may influence immune dynamics and therapeutic response, while its structural stability may serve as a potential modulatory factor. This hypothesis-generating observation suggests that CCR5 could represent a potential prognostic and predictive biomarker, particularly in NAC-refractory or immune-inflamed breast cancers.
Authors
- Leonard Wee (ORCID: https://orcid.org/0000-0003-1612-9055)
- André Dekker (ORCID: https://orcid.org/0000-0002-0422-7996)
- Deju Zhang (ORCID: https://orcid.org/0000-0001-5671-3227)
- Chuntao Quan
- En Hu (ORCID: https://orcid.org/0000-0003-1091-2233)
- Ni Xie (ORCID: https://orcid.org/0000-0002-7167-9343)
- Wenjie Liang (ORCID: https://orcid.org/0009-0000-3468-1930)
- Peiyu Qiu
Institutions
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Maastro Clinic (NL)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1007/s12672-025-04189-1
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00