Targeting PSMB5-induced PANoptosis in bladder cancer: multi-omics insights and TCM candidate discovery
A prognostic model incorporating PANoptosis-related genes was developed for stratifying BLCA risk and assessing the immune microenvironment. PSMB5 has been recognized as a crucial therapeutic target, exhibiting dual importance in the molecular etiology of BLCA and traditional Chinese medicine intervention.
Authors
- Xinpeng Fan
- Yalong Zhang (ORCID: https://orcid.org/0000-0002-9995-7659)
- Zhe Chang (ORCID: https://orcid.org/0000-0002-9720-803X)
- Jianwei Yang
- Siyu Chen (ORCID: https://orcid.org/0000-0002-7549-5840)
- Li Wang (ORCID: https://orcid.org/0000-0001-6944-1195)
- Yang Li (ORCID: https://orcid.org/0000-0002-6515-4567)
- Chenyang Wang (ORCID: https://orcid.org/0000-0001-6798-0857)
- Kunpeng Li (ORCID: https://orcid.org/0000-0003-3822-6198)
- Jian Wang
- Jiajia Cao (ORCID: https://orcid.org/0009-0007-1595-2767)
Institutions
- Lanzhou University Second Hospital (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1656682
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00