“PICS”: a novel patient-specific landmark for thalamic surgical interventions in the posterior limb of the internal capsule signal
PICS appears to be a reliable radiological marker comprising cortico-spinal tracts, in isolation from corticobulbar tracts fibers. It is consistently located lateral to the Vim, making it a potential landmark to infer Vim location and help refine targeting for thalamic procedures. The parcellations of the pLIC using M1 homunculus could potentially inform lead or ablation location based on side effect profiles (e.g., head/face/tongue vs. trunk/limbs). Therefore, proximity or distance to PICS may potentially guide lead placement to avoid procedure-related capsular side effects while optimizing benefits.
Authors
- Noam Harel (ORCID: https://orcid.org/0000-0002-6034-3801)
- Meghan Hill (ORCID: https://orcid.org/0000-0001-9019-1186)
- Joshua E. Aman (ORCID: https://orcid.org/0000-0003-1242-062X)
- Jerrold L. Vitek (ORCID: https://orcid.org/0000-0002-2308-6535)
- Leonardo Almeida (ORCID: https://orcid.org/0000-0002-0921-887X)
- Rémi Patriat (ORCID: https://orcid.org/0000-0003-2928-3772)
- Henry Braun (ORCID: https://orcid.org/0000-0001-7003-9822)
- Jayashree Chandrasekaran
- Karianne Sretavan
- Samuel Brenny
- Yasamin Seddighi
Institutions
- University of Minnesota (US)
- Resonance Research (United States) (US)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fnhum.2025.1707031
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00