Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study
Our findings suggest that regular AGPA is associated with markers of slower neurovascular aging in older individuals. AGPA induces a combination of general physical activity-related and specific AGPA-related effects; moreover, it may offer similar or even greater benefits than physical activity alone. Therefore, habitual AGPA may serve as an effective preventive strategy for neurovascular aging.
Authors
- Masato Nishiwaki (ORCID: https://orcid.org/0000-0003-2643-9532)
- Shotaro Otsuka (ORCID: https://orcid.org/0000-0003-3563-2473)
- Hyuma Makizako (ORCID: https://orcid.org/0000-0001-9898-675X)
- Seiya Takada (ORCID: https://orcid.org/0000-0002-8960-7233)
- Naoto Shiomi
- Harutoshi Sakakima (ORCID: https://orcid.org/0000-0002-6805-2742)
- Hisaaki Uchikado (ORCID: https://orcid.org/0000-0002-6082-0911)
- Kazuki Nakanishi (ORCID: https://orcid.org/0009-0003-3621-7172)
- Satomi Ooba
- Nobuhiro Tahara (ORCID: https://orcid.org/0000-0003-2011-8201)
- Naoyuki Matsumoto (ORCID: https://orcid.org/0000-0002-9619-3294)
- Kiyoshi Kikuchi
Institutions
- Kurume University (JP)
- Kagoshima University (JP)
- Shiga University of Medical Science (JP)
- Oita University (JP)
- Prefectural University of Kumamoto (JP)
- Ono Clinic (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Osaka Institute of Technology (JP)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fnagi.2025.1676259
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science