Gut-to-tumor translocation of multidrug-resistant Klebsiella pneumoniae shapes the microbiome and chemoresistance in pancreatic cancer
This study provides a comprehensive microbiome-based insight into PC and its metastatic subtypes. By integrating microbiome analysis with microbial culture, this study provides direct evidence of gut-derived multidrug-resistant (MDR) <i>K. pneumoniae</i> colonization in PC tissues.
Authors
- Xinyang Zhao (ORCID: https://orcid.org/0000-0001-7082-381X)
- BaoJian Xing
- Shifu Peng
- Muxi Ge
- Shenghui Yu
- Heyao Ma (ORCID: https://orcid.org/0000-0002-6148-792X)
- Cheng Zhang (ORCID: https://orcid.org/0000-0003-3647-7241)
- Jinyang Liu (ORCID: https://orcid.org/0000-0001-6170-435X)
- Lei Zhao (ORCID: https://orcid.org/0000-0003-0926-0944)
- Tong Yang (ORCID: https://orcid.org/0000-0002-7372-374X)
- Ziwei Miao
Institutions
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
- Nanjing Municipal Center for Disease Control And Prevention (CN)
- First Hospital of China Medical University (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fcimb.2025.1694479
- Citations
- 3
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.70