Effects of gut microbiota dysbiosis on the metabolism and pharmacokinetics of losartan in rats: from endogenous to ceftriaxone-induced dysbiosis
This study highlights that gut microbiota dysbiosis diminishes losartan bioavailability, providing evidence that gut microbiota contributes to the pharmacokinetic variability of losartan.
Authors
- Houshuang Huang
- Yanjun Hong (ORCID: https://orcid.org/0000-0003-3059-8130)
- Jiaxuan Xia (ORCID: https://orcid.org/0000-0002-5969-3812)
- Meifang Li (ORCID: https://orcid.org/0000-0002-9138-3080)
- Dan Li (ORCID: https://orcid.org/0000-0003-3461-5751)
- Bing Wang (ORCID: https://orcid.org/0000-0002-7287-0852)
- Cai Xu
- Yuefeng Ellen 章月鳳 Zhang (ORCID: https://orcid.org/0000-0001-9918-0280)
- Zhiyong Xie (ORCID: https://orcid.org/0000-0002-2147-6660)
- Yibao Jin
Institutions
- Sun Yat-sen University (CN)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Shenzhen Institute for Drug Control (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fmicb.2025.1693247
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81