Autologous matrix-induced chondrogenesis for management of osteo-chondral lesions of the talus: A pilot study

Objectives: Ankle discomfort is frequently caused by an osteo-chondral lesion (OCL) of the talus. The most frequent cause of this lesion is a traumatic incident, which can result in secondary osteoarthritis with pain and functional limitations if it is not identified and treated effectively. This study aimed to assess the outcomes of autologous matrix-induced chondrogenesis (AMIC) technique for the management of patients with OCL of the talus. Methods: A prospective case series pilot study involving 30 patients (18 males and 12 females) presented with OCL of the talus (17 on the right and 13 on the left side). Our patients’ average age was 36 years (17–56 years), with 12.6 months on average follow-up (6–20 months). Chronic symptom duration (over 2 years) was dominant, 40% having prior surgeries. Trauma, mainly ankle sprains, was the leading cause. All patients treated by the AMIC technique. Results: All patients demonstrated significant functional improvement. No serious intraoperative or postoperative complications were reported; 40% of patients experienced minor complications, while 60% had none. There is a highly significant improvement in the American Orthopedic Foot and Ankle Society score with an average of 31.03 ± 14.76, which increased from 49.10 ± 10.62 preoperatively to 80.13 ± 10.25 postoperatively. Conclusion: The use of the AMIC technique for managing OCL of the talus has demonstrated significant clinical and functional improvement in patients. It proved to be a secure and efficient option, promising a single-step cartilage repair strategy that preserves joint integrity and supports early functional recovery.