Branched tetrameric lactoferricin peptides modified with diaminopropionic acid exhibit potent antimicrobial and wound-healing activities
Together, these findings validate our peptide design strategy, revealing previously unknown characteristics of the LBT peptide and the enhanced multifunctionality achieved with LBT-1, supporting its continued development for chronic wound management.
Authors
- Nikitha Vavilthota
- Jan W. Drijfhout (ORCID: https://orcid.org/0000-0003-4808-5296)
- Sebastian A. J. Zaat (ORCID: https://orcid.org/0000-0001-9589-186X)
- Martijn Riool (ORCID: https://orcid.org/0000-0002-5444-3179)
- Leonie de Boer (ORCID: https://orcid.org/0000-0003-2899-0205)
- Robert A. Cordfunke (ORCID: https://orcid.org/0000-0002-7200-7434)
- Bouke K. H. L. Boekema (ORCID: https://orcid.org/0000-0002-9085-6982)
- Payal P. S. Balraadjsing (ORCID: https://orcid.org/0000-0003-4378-280X)
- Gizem Babuççu
Institutions
- Leiden University Medical Center (NL)
- University Hospital Regensburg (DE)
- Association of Dutch Burn Centres (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fphar.2025.1719557
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00