APOE ε4 allele drives female-specific Alzheimer’s disease progression via vascular dysfunction and tau spreading
we reveal a female-specific APOE ε4-driven molecular network linking endothelial dysfunction to tau pathology. These hub genes provide potential biomarkers, while vincamine represents a targeted prevention and therapeutic candidate for high-risk APOE ε4-positive women.
Authors
- Jiawei Wu (ORCID: https://orcid.org/0000-0001-7382-9993)
- Shuai Huang (ORCID: https://orcid.org/0000-0001-5238-071X)
- Ling He (ORCID: https://orcid.org/0009-0001-7457-7852)
Institutions
- Jiangsu University (CN)
- China Pharmaceutical University (CN)
- First People's Hospital of Kunshan (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fnins.2025.1683204
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16