Identification of MUC5B as a lymph node metastasis-associated gene in lung adenocarcinoma through integrated transcriptomic and machine learning approaches
MUC5B facilitates LUAD lymph node metastasis, potentially by regulating the GINS complex and promoting oncogenic signaling. These findings highlight MUC5B as a promising biomarker and therapeutic target for advanced LUAD.
Authors
- Minjun Du
- Jiacong Wei (ORCID: https://orcid.org/0000-0002-6672-7531)
- Linchuan Liang
- Yushun Gao (ORCID: https://orcid.org/0000-0003-3992-6671)
- Mianyang Li (ORCID: https://orcid.org/0009-0000-6093-4890)
- Weijian Song (ORCID: https://orcid.org/0000-0002-0293-2608)
- Boxuan Zhou (ORCID: https://orcid.org/0000-0002-1103-0059)
- Jianwei Shi (ORCID: https://orcid.org/0009-0005-5842-7570)
- Qian Yang (ORCID: https://orcid.org/0009-0009-9454-6648)
- Mei Liang (ORCID: https://orcid.org/0000-0002-9911-5654)
- Zixu Liu (ORCID: https://orcid.org/0000-0002-3082-6765)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Chinese PLA General Hospital (CN)
- National Cancer Center (US)
- National Clinical Research Center for Digestive Diseases (CN)
- National Center for Clinical Laboratories (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1666240
- Citations
- 2
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61