Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome
PANX1 channels appear to be important mediators of platelet activation in APS. Agents that block PANX1 may restore platelet homeostasis and limit thrombosis without impairing hemostasis.
Authors
- Jacqueline A. Madison (ORCID: https://orcid.org/0000-0003-1745-8133)
- Somanathapura K. NaveenKumar (ORCID: https://orcid.org/0000-0002-8991-5041)
- Bruna de Moraes Mazetto (ORCID: https://orcid.org/0000-0002-8778-4658)
- Jordan K. Schaefer (ORCID: https://orcid.org/0000-0002-7166-386X)
- Srilakshmi Yalavarthi (ORCID: https://orcid.org/0009-0005-9128-572X)
- Yu Zuo (ORCID: https://orcid.org/0000-0001-6721-7755)
- Cyrus Sarosh (ORCID: https://orcid.org/0009-0004-5371-1700)
- Fernanda Andrade Orsi (ORCID: https://orcid.org/0000-0002-7908-9073)
- Ajay Tambralli (ORCID: https://orcid.org/0000-0001-9056-9513)
- Jason S. Knight (ORCID: https://orcid.org/0000-0003-0995-9771)
- Tom Newman (ORCID: https://orcid.org/0000-0002-7987-9948)
- Michael Holinstat (ORCID: https://orcid.org/0000-0001-5100-1933)
- Kavya Sugur
- Claire K. Hoy
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1002/art.70001
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rheumatology Research Foundation
- National Research Foundation
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- National Institutes of Health