Photoinduced Deprotection of Tetrahydropyranyl Ethers with High Selectivity and Ultrahigh Efficiency
A photoinduced deprotection of tetrahydropyranyl (THP) ethers under mild and metal‐free conditions is reported. The transformation proceeded well in good to excellent yields (up to 98%) in the presence of 0.1 mol% of BrCCl 3 . THP ethers of both aliphatic alcohols and phenols were deprotected efficiently with high selectivity. Other acid‐sensitive protecting groups (AcO, NHBoc, and ketal) were well tolerated. This convenient methodology has also been successfully extended to typical natural product scaffolds, including amino acid derivative, sugar, and cholesterol derivatives.
Authors
- Yongna Lu (ORCID: https://orcid.org/0000-0002-2308-998X)
- Pinzhu Qin (ORCID: https://orcid.org/0000-0003-4471-8586)
- Xianhui Sun (ORCID: https://orcid.org/0009-0009-1408-566X)
- Xiamin Cheng (ORCID: https://orcid.org/0000-0001-6536-9077)
- Xin Yang (ORCID: https://orcid.org/0009-0002-6190-2588)
Institutions
- Ministry of Ecology and Environment (CN)
- The Synergetic Innovation Center for Advanced Materials (CN)
- Yunnan Open University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ejoc.202501089
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Nanjing Tech University