Physical activity and Alzheimer’s disease risk across genetic susceptibility: a prospective UK Biobank study using accelerometer data
Objectively measured PA substantially reduces AD risk regardless of genetic predisposition. Even light-intensity activity provides meaningful protection, supporting PA as a broadly applicable preventive strategy across all genetic risk levels.
Authors
- Seunghee Na (ORCID: https://orcid.org/0000-0001-8578-8578)
- Kenneth Muir (ORCID: https://orcid.org/0000-0001-6429-988X)
- Jongin Lee (ORCID: https://orcid.org/0000-0003-4337-8444)
- Y. Huang (ORCID: https://orcid.org/0000-0003-1826-2749)
- Artitaya Lophatananon
Institutions
- Manchester Academic Health Science Centre (GB)
- St. Mary's Hospital (US)
- The Catholic University of Korea Incheon St. Mary's Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1007/s00415-025-13524-z
- Primary Topic
- Physical Activity and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- European Commission
- HORIZON EUROPE Framework Programme
- Incheon St. Mary's Hospital, Catholic University of Korea