Intervertebral disc degeneration is accelerated by GH overexpression but attenuated by GH antagonism
Abundance of GH accelerates IVDD through sex-dependent activation of inflammatory and matrix-degrading pathways, while GH antagonism confers protection against age associated disc degeneration. These findings identify GH as a critical regulator of disc homeostasis and a potential therapeutic target for mitigating IVDD and associated low back pain.
Authors
- Abhijit Sukul (ORCID: https://orcid.org/0000-0001-5983-0920)
- Patrick M. O’Connor (ORCID: https://orcid.org/0000-0002-6762-3806)
- Shouan Zhu (ORCID: https://orcid.org/0000-0002-4973-1504)
- John J. Kopchick (ORCID: https://orcid.org/0000-0003-4561-2177)
- Simon Y. Tang (ORCID: https://orcid.org/0000-0002-5570-3921)
- Huanhuan Liu (ORCID: https://orcid.org/0000-0003-1790-3073)
- Siqi Ren (ORCID: https://orcid.org/0000-0002-1734-6230)
- Oladimeji Ajayi Akande
- Anna E. Miller
Institutions
- Washington University in St. Louis (US)
- Ohio University (US)
Publication Details
- Journal
- GeroScience
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1007/s11357-025-02022-9
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47