A Metastasis-Competent CAF Subpopulation Defined by MFAP5⁷THY1⁷ Co-expression Drives Prostate Cancer Metastasis via EMT Activation
We identified a metastasis-competent CAF subpopulation defined by MFAP5⁷THY1⁷ co-expression, where THY1 serves as a spatial anchor for MFAP5 detection and MFAP5 secretion is functionally linked to AKT/EMT pathway activation.
Authors
- Guohai Shi
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0282-601X)
- Jianhua Wang (ORCID: https://orcid.org/0000-0002-3901-9644)
- Jianghua Zheng (ORCID: https://orcid.org/0000-0003-1179-7986)
- Leilei Du (ORCID: https://orcid.org/0000-0002-3597-3596)
- Yu Wang (ORCID: https://orcid.org/0000-0003-1253-7465)
- Wenfeng Wang (ORCID: https://orcid.org/0000-0003-4083-4344)
- Wenhao Xu (ORCID: https://orcid.org/0000-0002-0660-9162)
- Xingming Zhang (ORCID: https://orcid.org/0000-0001-8239-5410)
- Yongqiang Huang
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Ninth People's Hospital (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Recent Patents on Anti-Cancer Drug Discovery
- Published
- 2025-11-26
- DOI
- https://doi.org/10.2174/0115748928439833251118072935
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00