Expression characteristics, prognostic value, and immune-related analysis of PPP2R1A in lung adenocarcinoma
PPP2R1A is overexpressed in LUAD and associated with poor prognosis, potentially serving as an oncogene by regulating key signaling pathways and immune microenvironment. Its knockdown suppresses malignant phenotypes, highlighting its potential as both a prognostic biomarker and therapeutic target in LUAD.
Authors
- Yuhong Hu (ORCID: https://orcid.org/0000-0001-7423-1643)
- Mingyou Dong
- Shanshan Xiao (ORCID: https://orcid.org/0000-0002-3430-0701)
- Yawen Li (ORCID: https://orcid.org/0009-0004-6013-0787)
- Lusheng Liao (ORCID: https://orcid.org/0000-0002-3920-3900)
- Zijun Xiao
- Xin Zhang (ORCID: https://orcid.org/0000-0001-6036-2685)
Institutions
- Guangxi Minzu University (CN)
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1652629
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00