The Association Between Body Weight Variability and Dementia and Cognitive Decline: A Systematic Review and Meta‐Analysis of Cohort Studies With the GRADE Assessment
High body weight fluctuation is associated with an elevated risk of dementia, particularly Alzheimer's disease and vascular dementia. These findings highlight weight stability as a potential target for dementia prevention strategies. Further high-quality studies are warranted to clarify underlying mechanisms and long-term implications.
Authors
- Ali Vasheghani‐Farahani (ORCID: https://orcid.org/0000-0003-3346-2124)
- Amir Hossein Memari (ORCID: https://orcid.org/0000-0002-8302-1821)
- Zahra Gohari Dezfuli (ORCID: https://orcid.org/0000-0001-5813-6283)
- Dorsa Salabat (ORCID: https://orcid.org/0000-0002-1585-5808)
- Negar Bafkar (ORCID: https://orcid.org/0009-0008-2511-4190)
- Shadi Ghaemi (ORCID: https://orcid.org/0000-0002-4623-326X)
- Minoo HasanRashedi
Institutions
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Obesity Reviews
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/obr.70055
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00