A study on the correlation of thyroid nodules with METS-IR and SII in a population undergoing health checkups
Thyroid nodules are highly prevalent, particularly among women and older individuals. Lower-grade nodules (TI-RADS 2 and 3) show an inverse correlation with TSH levels, whereas higher-grade nodules (TI-RADS 3 and ≥4) are independently linked to increased insulin resistance (METS-IR) and systemic inflammation (SII). These findings suggest that METS-IR and SII could serve as valuable biomarkers for thyroid nodule assessment.
Authors
- Xiangsheng Cai (ORCID: https://orcid.org/0000-0002-6353-8188)
- Chuanjiang Ye
- Ruoping Guan
- Guohao Dai (ORCID: https://orcid.org/0000-0001-7346-2685)
Institutions
- Guangzhou Center for Disease Control and Prevention (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fendo.2025.1665432
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Project