TRAP1 induced cisplatin resistance in gastric cancer cells by regulating oxidative stress
These findings indicated that TRAP1 attenuated CDDP sensitivity in GC cells by reducing cell death caused by CDDP-induced oxidative stress. TRAP1 represented a potential biomarker and a therapeutic target in GC treatment. This study provided a new strategy for improving the efficacy of CDDP-based chemotherapy through individualized treatment approaches.
Authors
- Lu Liu (ORCID: https://orcid.org/0000-0003-3906-328X)
- Huazhang Wu (ORCID: https://orcid.org/0000-0002-5482-3761)
- Jingya Chen (ORCID: https://orcid.org/0000-0002-4854-6462)
- Yunli Zhao
- Wenshuai Zhu (ORCID: https://orcid.org/0000-0001-9027-1290)
- Zhenyu Ji (ORCID: https://orcid.org/0000-0002-7871-6880)
Institutions
- Bengbu Medical College (CN)
- Anhui Science and Technology University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fmolb.2025.1676811
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bengbu Medical College
- Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province