Predictors of delayed hyponatremia after endoscopic transsphenoidal surgery for non-functioning pituitary adenomas

This study identified the independent risk factors for delayed hyponatremia in patients with NFPA after TSS, including higher preoperative TSH level, intraoperative CSF leak, lower serum sodium of POD 1 and meningitis. However, patients with hypertension had a higher likelihood of avoiding DPH. It is recommended that DPH should be closely monitored after endoscopic TSS, especially in patients without hypertension. Furthermore, a multicenter prospective trial with an expanded sample size is warranted to investigate the etiology of DPH after endoscopic TSS.