Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration
This study elucidates the genetic signatures associated with macrophages and their immune regulatory mechanisms in LDD, identifies potential diagnostic biomarkers and therapeutic targets, and proposes new strategies for precision intervention.
Authors
- Bin Dai (ORCID: https://orcid.org/0000-0002-6495-0262)
- Junchen Zhu (ORCID: https://orcid.org/0009-0003-0967-8619)
- Danyang Li (ORCID: https://orcid.org/0000-0002-7508-6019)
- Xun Xiang (ORCID: https://orcid.org/0000-0001-9943-9977)
- Hongxing Zhang (ORCID: https://orcid.org/0000-0002-5934-8912)
- Minglei Gao
- Jiafeng Peng
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Shenzhen Luohu People's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1671961
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00