Serum and urine anti-PLA2R antibody correlation with albuminuria in idiopathic membranous nephropathy
In patients with IMN, serum anti-PLA2R antibody concentrations are inversely associated with plasma albumin, while urine anti-PLA2R antibody levels are positively associated with 24-hour urine protein quantification. These findings suggest that combined assessment of serum and urine anti-PLA2R antibody levels may provide valuable insights into disease activity and albuminuria in IMN. Further studies with larger cohorts are needed to validate these findings and explore their potential clinical implications.
Authors
- Yamin Fu (ORCID: https://orcid.org/0009-0001-4993-9903)
- Manshu Sui (ORCID: https://orcid.org/0000-0003-2574-6442)
- Zizhen Li (ORCID: https://orcid.org/0000-0001-7424-8779)
- Xiaogang Liu (ORCID: https://orcid.org/0000-0003-4099-6693)
- Xuehua Wang (ORCID: https://orcid.org/0000-0002-5317-6822)
Institutions
- Harbin Medical University (CN)
- Beihai People's Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1670960
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00