Management and outcomes in pregnant patients with monogenic diabetes due to pathogenic variants in GCK and HNF1A genes
Pregnancy outcomes in patients with subtypes of monogenic diabetes: GCK-hyperglycemia and HNF1A were comparable and generally favorable. Individualized insulin therapy, regular monitoring and structured outpatient care support safe management even without fetal genotyping, though universal insulin in GCK subtypes diverges from emerging genotype-based practice.
Authors
- Karolina Zawadzka (ORCID: https://orcid.org/0000-0002-6918-4683)
- Michał Kania (ORCID: https://orcid.org/0000-0002-4288-1024)
- Przemysław Witek (ORCID: https://orcid.org/0000-0003-4512-4624)
- Katarzyna Cyganek (ORCID: https://orcid.org/0000-0003-2673-3512)
- Magdalena Szopa
Institutions
- Jagiellonian University (PL)
- Krakow Cardiovascular Research Institute (PL)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fendo.2025.1687596
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Jagielloński Collegium Medicum
- Agencja Badań Medycznych