Oil-based and oil-free formulations for enhancing cannabidiol bioavailability
CBD bioavailability can be substantially enhanced by formulation design. Medium-sized emulsions (≈ 16 μm) provided the most pronounced improvement, while oil-free particles offered additional but less size-dependent benefits. Excessive surfactant (Tween 20) or lecithin content negatively impacted systemic exposure, underscoring the need for balanced formulation strategies. These findings contribute to the understanding of oral delivery of lipophilic compounds and support the rational development of optimized CBD formulations for therapeutic applications.
Authors
- Ondřej Slanař (ORCID: https://orcid.org/0000-0002-5357-7562)
- Petr Kozlík (ORCID: https://orcid.org/0000-0002-0907-7528)
- Tomáš Křížek (ORCID: https://orcid.org/0000-0002-1623-8844)
- Pavel Ryšánek (ORCID: https://orcid.org/0000-0001-6727-1663)
- Martin Šíma (ORCID: https://orcid.org/0000-0002-6541-738X)
- Miroslav Šoóš (ORCID: https://orcid.org/0000-0002-9742-7160)
- Petr Jelínek (ORCID: https://orcid.org/0000-0002-1374-9112)
- Armia George
- Hynek Housar (ORCID: https://orcid.org/0009-0001-1913-7328)
- Anežka Klouček
Institutions
- Charles University (CZ)
- General University Hospital in Prague (CZ)
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Journal of Cannabis Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s42238-025-00371-y
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00