Editorial for <i>Revista Portuguesa de Oncologia</i>, issue 4, 2025

As we bring to a close the fourth and final issue of the Revista Portuguesa de Oncologia (RPO) for this year, a brief reflection is warranted on the recent trajectory of this publication, which is increasingly and consistently affirming itself as an active and representative voice of the national oncology community.The year 2025 witnessed a noteworthy rise in both the number of submissions and published articles -a clear testament to the scientific vitality that inspires professionals devoted to oncology in Portugal.The RPO has endeavored to mirror this vigor and, at the same time, serve as a platform for the dissemination and affirmation of national scientific output, along a path that aspires to ever-greater visibility and relevance within the international editorial landscape.In this issue, we conclude our coverage of the Best of ASCO 2025 with articles dedicated to presentations concerning digestive and gynecological tumors -domains in constant evolution and of broad clinical impact.We further highlight the publication of an early-stage research project, with results yet to be determined, underscoring its value as an original article and a meaningful contribution to the journal's indexing process.In doing so, we are reminded that science is also built upon the sharing of foundational knowledge, and not solely on its final outcomes.We extend our sincere gratitude to all authors, reviewers, and readers who, through their dedication and rigor, have contributed to the sustained growth of the RPO, which aspires to be an ever more prominent forum for the dissemination of oncological scientific research.With best wishes for an excellent 2026,