Traditional Chinese Medicinal Leech Induces Apoptosis and Autophagy in Glioblastoma by <scp>SGK1</scp> /Caspase‐3 and <scp>PI3K</scp> / <scp>AKT</scp> / <scp>mTOR</scp> Pathway
The leech-derived compounds may induce apoptosis and autophagy in GBM by modulating the PI3K/AKT/mTOR signaling pathway, without eliciting significant adverse effects, thereby presenting itself as a promising therapeutic agent.
Authors
- Zhuan Pei (ORCID: https://orcid.org/0000-0002-7869-0385)
- Yaya Zhou (ORCID: https://orcid.org/0009-0005-8183-0341)
- Yang Wang (ORCID: https://orcid.org/0000-0003-0447-3107)
- Zuping Zhang (ORCID: https://orcid.org/0000-0002-3295-2861)
- Shaohua Wu (ORCID: https://orcid.org/0009-0000-3657-635X)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cns.70683
- Primary Topic
- Leech Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00