L. johnsonii alleviates methamphetamine craving via the metabolism of tyrosine
Our results reveal that MA addiction disrupts gut microbiota homeostasis and promotes tyrosine-mediated dopamine system dysfunction. L. johnsonii transplantation is recommended for the treatment of methamphetamine craving.
Authors
- Peng Xu (ORCID: https://orcid.org/0009-0000-6923-0101)
- Dongsheng Liu (ORCID: https://orcid.org/0000-0002-2053-1752)
- Hui Xu (ORCID: https://orcid.org/0009-0003-2994-9834)
- Yuan Xie (ORCID: https://orcid.org/0000-0001-9822-7374)
- Sheng Wei (ORCID: https://orcid.org/0000-0003-0145-3258)
- Guangji Wang (ORCID: https://orcid.org/0000-0002-3297-6732)
- Ran Zhang (ORCID: https://orcid.org/0000-0002-6021-5367)
- Zhihao Cheng (ORCID: https://orcid.org/0000-0002-8360-5149)
- Jiye Aa
- Qin Shao
- Youmei Wang
Institutions
- Ministry of Public Security of the People's Republic of China (CN)
- China Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Natural Medicine
Publication Details
- Journal
- Microbiome
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s40168-025-02197-5
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81