Adjuvant roles of interleukin-7 in enhancing T cell recovery during antiretroviral therapy for individuals with HIV: a systematic review and meta-analysis
Our analysis revealed that IL-7 can induce an increase in CD4<sup>+</sup> and CD8<sup>+</sup> T cell counts in individuals with HIV receiving long-term ART, aiding in immune system reconstitution and increasing the HIV DNA load in the whole blood. These findings suggest that while IL-7 holds promise as an adjuvant strategy for immune restoration, its long-term impact on HIV persistence must be weighed in clinical application.
Authors
- Ruixi Zhou (ORCID: https://orcid.org/0000-0002-4409-1595)
- Tiechao Ruan (ORCID: https://orcid.org/0000-0002-2924-0230)
- Dezhi Mu (ORCID: https://orcid.org/0000-0002-2599-7041)
- Wenting Lu (ORCID: https://orcid.org/0000-0002-6161-890X)
- Xia Qiu (ORCID: https://orcid.org/0000-0002-3694-7357)
- Bixin Deng (ORCID: https://orcid.org/0009-0003-2546-9390)
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1080/07853890.2025.2594303
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00