Targeting ubiquitin-specific protease 14 reduces metastatic potential and metabolic activity in cervical cancer via direct modulation of monocarboxylate transporter-4
This study uncovers MCT4 as a novel substrate of USP14, linking USP14 activity to metabolic reprogramming in CC. The USP14-MCT4 axis represents a previously unrecognized oncogenic pathway with therapeutic potential. Targeting USP14 could simultaneously impair tumor growth and disrupt lactate metabolism, offering a promising strategy for CC treatment.
Authors
- Shahab Uddin (ORCID: https://orcid.org/0000-0003-1886-6710)
- Sandeep Mathur (ORCID: https://orcid.org/0000-0002-6729-6833)
- Sameer Mirza (ORCID: https://orcid.org/0000-0002-9394-2421)
- Mukesh Tanwar (ORCID: https://orcid.org/0000-0003-0370-0371)
- Ammira S. Al-Shabeeb Akil
- Tej K. Pandita (ORCID: https://orcid.org/0000-0002-2365-5937)
- Lakshay Malhotra (ORCID: https://orcid.org/0000-0001-6700-5330)
- Pranay Tanwar
- Gunjan Dagar
- Harit Kapoor (ORCID: https://orcid.org/0000-0003-2426-0643)
- Muzafar A. Macha (ORCID: https://orcid.org/0000-0003-4468-4435)
- Ashna Gupta
- A.S. Ethayathulla (ORCID: https://orcid.org/0000-0001-8958-3916)
- Rajat Ujjainiya (ORCID: https://orcid.org/0000-0002-5090-0432)
- Lakshmana Das (ORCID: https://orcid.org/0009-0003-7761-7789)
- Hemant Kumar Yadav (ORCID: https://orcid.org/0000-0002-4193-8199)
- Ajaz Ahmad Bhat (ORCID: https://orcid.org/0000-0003-3640-6275)
- Mayank Yadav (ORCID: https://orcid.org/0000-0001-9821-6309)
- Ravi Chauhan
- Archana Singh (ORCID: https://orcid.org/0000-0003-1388-9489)
- Anju Surendranath
Institutions
- University of Delhi (IN)
- Texas A&M Health Science Center (US)
- Qatar Airways (Qatar) (QA)
- Institute of Genomics and Integrative Biology (IN)
- United Arab Emirates University (AE)
- Sidra Medical and Research Center (QA)
- Islamic University of Science and Technology (IN)
- Hamad Medical Corporation (QA)
- All India Institute of Medical Sciences (IN)
- Maharshi Dayanand University (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12967-025-07442-x
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00