Preventive effects of vitamin D on epileptic seizures and its regulation of PTEN and autophagy in acute epilepsy mouse models
(1) PTZ-induced seizures increased CaSR and decreased PTEN, triggering autophagy and worsening symptoms. (2) KA-induced epilepsy caused more severe damage with stronger autophagy activation. (3) VitD pretreatment mitigated seizures by modulating CaSR, PTEN, and autophagy, showing greater efficacy in the PTZ model.
Authors
- Lei Liu (ORCID: https://orcid.org/0000-0002-3710-7042)
- Jin Guo (ORCID: https://orcid.org/0000-0002-6149-9875)
- Shaobo Zhou (ORCID: https://orcid.org/0000-0001-5214-2973)
- Luchuan Wang
- Rong Fu (ORCID: https://orcid.org/0000-0002-6492-2608)
- Pei Zeng
- Ru‐Shi Liu (ORCID: https://orcid.org/0000-0002-1291-9052)
- Liya Fang
- De‐Ming Kong (ORCID: https://orcid.org/0000-0002-9216-8040)
- Jiahao Liu (ORCID: https://orcid.org/0000-0001-7799-2616)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0001-6862-1928)
- Chao Gong (ORCID: https://orcid.org/0000-0003-0187-6779)
- Zhimei Jiang
- Jiawei Li (ORCID: https://orcid.org/0000-0001-9957-8192)
Institutions
- Jiamusi University (CN)
- First Affiliated Hospital of Jiamusi University (CN)
- First People's Hospital of Jingzhou (CN)
- University of Greenwich (GB)
Publication Details
- Journal
- Nutritional Neuroscience
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1080/1028415x.2025.2592265
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00