Immune and Long Interspersed Nuclear Element-1 Dysregulation in Schizophrenia: An Exploratory Case–Control Study in a Brazilian Cohort with Ultra-Treatment Resistance
These findings reveal a distinct immune-epigenetic signature associated with treatment resistance in schizophrenia. Immune activation, Th17 signaling, and LINE-1 dysregulation may underlie the UTRS phenotype. Given the limited sample size and post hoc power analysis, the results should be regarded as exploratory and hypothesis-generating, warranting replication in larger cohorts.
Authors
- Maria Francilene Souza Silva (ORCID: https://orcid.org/0000-0002-4509-1159)
- Saulo Giovanni Castor Albuquerque
- Carolina Saraiva Nunes de Pinho
- Hoanna Izabely Rêgo Castro (ORCID: https://orcid.org/0000-0001-5646-4902)
- Clarissa Severino Gama (ORCID: https://orcid.org/0000-0003-2235-9690)
- Joel Porfírio Pinto (ORCID: https://orcid.org/0000-0001-6084-7818)
- Lia Lira Olivier Sanders (ORCID: https://orcid.org/0000-0002-3823-9821)
- David Freitas de Lucena (ORCID: https://orcid.org/0000-0002-1547-3711)
- Dino Cesar da Silva Clemente
- João Alexandre Lôbo Marques (ORCID: https://orcid.org/0000-0002-6472-8784)
- Paulo Levi Bezerra Martins
- Eugênio de Moura Campos (ORCID: https://orcid.org/0000-0002-9104-7888)
- David Gomes Araújo Júnior (ORCID: https://orcid.org/0000-0003-0755-2118)
- Débora Ferreira de Assis (ORCID: https://orcid.org/0000-0003-0750-5784)
- Caio Andrade de Oliveira
- Natália Gindri Fiorenza
- Danielle S. Macêdo (ORCID: https://orcid.org/0000-0001-8980-9970)
- Bruno Riccelli dos Santos Silva (ORCID: https://orcid.org/0000-0001-8189-7187)
- Jaime E. C. Hallak (ORCID: https://orcid.org/0000-0002-8784-0189)
- Marylane da Silva Viana
- Camilla Beatriz Marinho Teles
- Raylha Farias Tavares
- Manoela de Oliveira Rebouças
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Universidade Federal do Ceará (BR)
- Instituto Federal de Educação, Ciência e Tecnologia do Ceará (BR)
- Universidade de Fortaleza (BR)
- Instituto Superior de Teologia Aplicada (BR)
- University of Saint Joseph (CN)
- Mental Illness Fellowship (AU)
- Hospital Geral de Fortaleza (BR)
- University of Minho (PT)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1093/schbul/sbaf209
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00