Anti-survival of motor neuron antibodies in rheumatic and musculoskeletal diseases: prevalence, clinical associations, and biomarker potential, with novel insights into disease activity in SLE
Anti-SMN antibodies are prevalent in MCTD and SLE. Consistent with prior studies, their titers in MCTD were associated with distinct clinical features. Importantly, we newly demonstrate that in SLE, anti-SMN antibody levels correlate with immune complex-related manifestations and disease activity, providing a novel and clinically significant insight. These findings highlight their potential as biomarkers for disease stratification, organ involvement, and monitoring disease progression in RMDs.
Authors
- Jun Kikuchi (ORCID: https://orcid.org/0000-0003-3231-8841)
- Yuko Kaneko (ORCID: https://orcid.org/0000-0003-2646-5765)
- Keiko Yoshimoto (ORCID: https://orcid.org/0000-0002-6491-267X)
- Kazunori Furuhashi
- Koji Suzuki (ORCID: https://orcid.org/0000-0003-1358-7069)
- Masaru Takeshita (ORCID: https://orcid.org/0000-0002-3281-6595)
- Kotaro Matsumoto (ORCID: https://orcid.org/0000-0003-2047-7626)
- Yuki Imai (ORCID: https://orcid.org/0000-0003-0729-9810)
- Hiroyuki Fukui (ORCID: https://orcid.org/0009-0004-8401-8044)
Institutions
- Keio University (JP)
- Keio University Hospital (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s41232-025-00399-w
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00