Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats
Therapeutic subthalamic DBS activates the target region and modulates global brain function by restoring OFF-state hypometabolism in the ipsilateral subthalamic-substantia nigra loop and by reducing metabolic activity in the bilateral cortico-striatal circuitry. A reverse-translational pipeline is established to study stimulation-induced modulation of brain function, integrating a novel positron emission tomography template aligned with the Waxholm space of Sprague-Dawley rats.
Authors
- Nu‐Chu Liang (ORCID: https://orcid.org/0000-0001-5839-5533)
- Jens Volkmann (ORCID: https://orcid.org/0000-0002-9570-593X)
- Takahiro Higuchi (ORCID: https://orcid.org/0000-0001-9711-7835)
- Muthuraman Muthuraman (ORCID: https://orcid.org/0000-0001-6158-2663)
- Ningfei Li (ORCID: https://orcid.org/0000-0003-3315-3591)
- Chi Wang Ip (ORCID: https://orcid.org/0000-0003-0484-385X)
- Jia Zhi Chen (ORCID: https://orcid.org/0009-0008-2547-3513)
Institutions
- Humboldt-Universität zu Berlin (DE)
- Universitäts-Kinderklinik Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s40035-025-00523-3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00