Co-infection and interaction of enteric pathogens in acute diarrhea among children under five years: a large-scale multicenter observational study from China
This study demonstrates the frequent occurrence of co-infections in diarrheal children, and enteric pathogens may interact synergistically or antagonistically. It highlights the central role of RVA in exacerbating the severity of these co-infections. The findings emphasize the critical role of RVA vaccination in alleviating the burden and severity of diarrhea. Trial Registration The study was registered in the Chinese Clinical Trial Registry (ChiCTR-ROC-17013620).
Authors
- Guanghua Chen (ORCID: https://orcid.org/0000-0003-1388-5584)
- Mu-Xin Chen
- Canjun Zheng
- Shun-Xian Zhang (ORCID: https://orcid.org/0000-0002-8929-4433)
- Ruitao Liu (ORCID: https://orcid.org/0000-0003-3360-0451)
- Shi‐Zhu Li (ORCID: https://orcid.org/0000-0003-3172-5218)
- Wanfu Xu
- Qingjuan Zuo (ORCID: https://orcid.org/0000-0001-6073-3490)
- Hongli Wang (ORCID: https://orcid.org/0009-0009-6297-4250)
- Qin Liu (ORCID: https://orcid.org/0000-0001-9964-580X)
- Yu Qin (ORCID: https://orcid.org/0000-0003-4196-9291)
- Jinxin Zheng (ORCID: https://orcid.org/0000-0003-1476-1903)
- Wenwen Lv
- Shan Lv (ORCID: https://orcid.org/0000-0003-2086-807X)
- Li-Guang Tian
- Lei Duan
- Ji-Chun Wang
- Jian Yang (ORCID: https://orcid.org/0000-0003-4255-9622)
Institutions
- National Institute for Parasitic Diseases (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Ministry of Agriculture (BW)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Guangzhou Women and Children Medical Center (CN)
- Vector (United States) (US)
- Hospital for Tropical Diseases (VN)
- Institute for Forecasting of the Slovak Academy of Sciences (SK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s40249-025-01392-8
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- Shanghai Municipal Health Commission
- Science and Technology Commission of Shanghai Municipality
- Chinese Center for Disease Control and Prevention
- Shanghai University of Traditional Chinese Medicine
- National Key Research and Development Program of China