Ultrasmall glutathione-protected Au/Cu and their alloy nanoclusters with specific ROS generation
In this study, three glutathione (GSH)-protected nanoclusters ([Au<sub>5</sub>(SG)<sub>3</sub>]<sup>-</sup>, [Au<sub>9</sub>Cu<sub>2</sub>(SG)<sub>7</sub>]<sup>3-</sup> and [Cu<sub>7</sub>(SG)<sub>5</sub>]<sup>3+</sup>) were synthesized and characterized by ESI-MS, EPR, NMR and XPS. Each cluster exhibits a specificity in generating a distinct reactive oxygen species (ROS), specifically hydroxyl radicals (˙OH), singlet oxygen (<sup>1</sup>O<sub>2</sub>), or superoxide anions (O<sub>2</sub>˙<sup>-</sup>), under ambient conditions. This unique performance highlights not only the clusters' structural and functional specificity in ROS generation, but also their promising potential for advancing bioclinical applications.
Authors
- Lingxin Chen (ORCID: https://orcid.org/0000-0002-3764-3515)
- Haizhu Yu
- Weimin Sun (ORCID: https://orcid.org/0000-0003-1754-1236)
- Manzhou Zhu (ORCID: https://orcid.org/0000-0002-3068-7160)
- Xuejiao Yang
- Jing Jin (ORCID: https://orcid.org/0009-0000-8211-0227)
- T.J. Pan
- Zicheng Wanyan
Institutions
- Anhui University (CN)
Publication Details
- Journal
- Nanoscale
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1039/d5nr04022a
- Primary Topic
- Nanocluster Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00