White Matter Microstructure Alterations in Social Anxiety Disorder: A Mega-Analysis Across Twelve Cohorts in the ENIGMA-Anxiety Working Group
Using a mega-analytic approach, several differences in WM microstructure were found between individuals with SAD and HC participants, both in the full sample and in age group-specific sensitivity analyses. Some neurobiological changes in WM tracts in individuals with SAD may vary with age and sex, whereas others may relate to broader transdiagnostic neurobiological features underlying psychopathology. Further research should investigate these issues in more detail.
Authors
- Jacqueline A. Clauss (ORCID: https://orcid.org/0000-0002-0532-6726)
- Daniel S. Pine (ORCID: https://orcid.org/0000-0002-4301-9516)
- Andreas Jansen (ORCID: https://orcid.org/0000-0002-3140-8207)
- Su Lui (ORCID: https://orcid.org/0000-0003-3541-1769)
- Si Gao
- Benjamín Straube (ORCID: https://orcid.org/0000-0003-4391-1720)
- Eline F. Roelofs (ORCID: https://orcid.org/0000-0003-2712-7864)
- Elisabeth Johanna Leehr (ORCID: https://orcid.org/0000-0002-9264-5003)
- Sophia I. Thomopoulos (ORCID: https://orcid.org/0000-0002-0046-4070)
- Raquel E. Gur (ORCID: https://orcid.org/0000-0002-4082-8502)
- Robert R. J. M. Vermeiren (ORCID: https://orcid.org/0000-0002-8673-2207)
- Thomas Straube
- Neda Jahanshad (ORCID: https://orcid.org/0000-0003-4401-8950)
- Peter Kochunov (ORCID: https://orcid.org/0000-0003-3656-4281)
- Dominik Grotegerd (ORCID: https://orcid.org/0000-0001-8718-0128)
- P. Michiel Westenberg (ORCID: https://orcid.org/0000-0001-9138-7703)
- Hannah Meinert (ORCID: https://orcid.org/0000-0002-2230-0966)
- Tim Hahn (ORCID: https://orcid.org/0000-0002-8929-4134)
- Nic J.A. van der Wee (ORCID: https://orcid.org/0000-0003-3235-1633)
- Alex Doruyter (ORCID: https://orcid.org/0000-0001-9294-1737)
- Jochen Bauer (ORCID: https://orcid.org/0000-0001-9345-2126)
- Bart Larsen
- David Hofmann (ORCID: https://orcid.org/0000-0003-3494-634X)
- Igor Nenadić (ORCID: https://orcid.org/0000-0002-0749-7473)
- Frederike Stein (ORCID: https://orcid.org/0000-0002-5052-6022)
- Kinga Farkas (ORCID: https://orcid.org/0000-0002-1125-3957)
- Suzanne N. Avery (ORCID: https://orcid.org/0000-0002-5320-4619)
- Alyssa H. Zhu (ORCID: https://orcid.org/0000-0003-0083-5107)
- Udo Dannlowski (ORCID: https://orcid.org/0000-0002-0623-3759)
- Tilo T. J. Kircher (ORCID: https://orcid.org/0000-0002-2514-2625)
- Monica E. Calkins (ORCID: https://orcid.org/0000-0002-0546-0263)
- Nynke A. Groenewold (ORCID: https://orcid.org/0000-0002-0865-8427)
- Tamer Demıralp (ORCID: https://orcid.org/0000-0002-6803-734X)
- Dan Joseph Stein (ORCID: https://orcid.org/0000-0001-7218-7810)
- Anna Kraus (ORCID: https://orcid.org/0000-0003-2627-4563)
- André Zugman (ORCID: https://orcid.org/0000-0002-6126-7759)
- Janna Marie Bas‐Hoogendam (ORCID: https://orcid.org/0000-0001-8982-1670)
- Christine Löchner (ORCID: https://orcid.org/0000-0002-4766-3704)
- Raşit Tükel (ORCID: https://orcid.org/0000-0001-9421-4541)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Ruben C Gur
- Jennifer Urbano Blackford
- Tiana Borgers
- Kira Flinkenflügel (ORCID: https://orcid.org/0000-0001-7738-5429)
- Theresa Maria Slump
- Theodore D Sattertwaithe
- Roman A Vogler
Institutions
- Semmelweis University (HU)
- South African Medical Research Council (ZA)
- University of Southern California (US)
- Leiden University (NL)
- University of Minnesota (US)
- Nebraska Medical Center (US)
- Children's Hospital of Philadelphia (US)
- University of Cape Town (ZA)
- Philipps University of Marburg (DE)
- University of Münster (DE)
- Sichuan University (CN)
- Stellenbosch University (ZA)
- Hospital of the University of Pennsylvania (US)
- Leiden University Medical Center (NL)
- Massachusetts General Hospital (US)
- West China Hospital of Sichuan University (CN)
- University Hospital Münster (DE)
- NeuroDevelopment Center (US)
- National Institute of Mental Health (US)
- The University of Texas Health Science Center (US)
- Imaging Center (US)
- University of Houston (US)
- University of Nebraska Medical Center (US)
- Istanbul University (TR)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.bpsc.2025.11.007
- Primary Topic
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00