Regioselective β-organoseleno/α-,N <sup>2</sup> -tetrazole addition to alkenes
A method for the regioselective β-organoseleno/α-,N<sup>2</sup>-tetrazole addition to alkenes is reported. PhSeCl acts dually as a selenylating agent and a bridging agent for blocking the N<sup>1</sup> position of tetrazoles, thereby directing selectivity towards the N<sup>2</sup> position. The reactions show a broad substrate scope, accommodating various tetrazoles and alkenes, and are executed under mild conditions.
Authors
- Lifang Tian (ORCID: https://orcid.org/0000-0001-8747-7669)
- Yingying Tian (ORCID: https://orcid.org/0000-0001-8894-576X)
- Guanglu Liu
- Zijian Zhang (ORCID: https://orcid.org/0000-0003-4414-608X)
- Qinying Li (ORCID: https://orcid.org/0009-0009-0963-2067)
- Xiaofeng Han
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6825-5649)
- Yahui Wang (ORCID: https://orcid.org/0000-0003-4109-8318)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Jiawei Li
Institutions
- Nanjing Tech University (CN)
- Zhoukou Normal University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1039/d5ob01622c
- Primary Topic
- Synthesis of Tetrazole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00