Functional and structural impacts of oncogenic missense variants on human polo-like kinase 1 protein
The nsSNPs in PLK1 may perturb conformational stability and functions of the protein. Further experimental validation and discovery of novel inhibitors might develop mutation-specific interventions in precision oncology.
Authors
- Venkatraman Manickam (ORCID: https://orcid.org/0000-0001-5668-100X)
- Gayatri Munieswaran
Institutions
- Vellore Institute of Technology University (IN)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fbinf.2025.1680578
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00