Pediatric Oncology Patients With Germline Pathogenic Variants in Adult-Onset Cancer Predisposition Genes
These findings contribute to the literature suggesting that, rarely, GPV in aoCPG may contribute to cancer diagnoses in children, raising the question of how tumors in these cases may present differently in children than adults. Increased knowledge about potential childhood cancer risks related to what have historically been considered aoCPG could modify predictive genetic testing recommendations for children and enhance existing cancer screening protocols.
Authors
- Carl Koschmann (ORCID: https://orcid.org/0000-0002-0825-7615)
- Arul M. Chinnaiyan (ORCID: https://orcid.org/0000-0001-9282-3415)
- Rajen J. Mody (ORCID: https://orcid.org/0000-0001-5574-1779)
- Andrea M. Murad (ORCID: https://orcid.org/0000-0003-0423-4966)
- Erika Koeppe (ORCID: https://orcid.org/0000-0002-9775-6327)
- Sarah Austin (ORCID: https://orcid.org/0000-0003-4484-9746)
- Andrea Franson (ORCID: https://orcid.org/0000-0002-5361-7683)
- Denise Leung (ORCID: https://orcid.org/0000-0003-4302-0098)
- Patricia L. Robertson (ORCID: https://orcid.org/0000-0001-8623-1309)
- Dan R. Robinson (ORCID: https://orcid.org/0000-0002-2337-7439)
- Michelle F. Jacobs (ORCID: https://orcid.org/0000-0002-0458-1952)
- Chandan Kumar‐Sinha (ORCID: https://orcid.org/0000-0002-8696-3400)
- Yi-Mi Wu
- Josh N. Vo
Institutions
- University of Michigan (US)
- Michigan Center for Translational Pathology (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1200/po-24-00749
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00