Amivantamab Plus Lazertinib in Atypical <i>EGFR</i> -Mutated Advanced Non–Small Cell Lung Cancer: Results From CHRYSALIS-2
In participants with atypical <i>EGFR</i>-mutated advanced NSCLC, amivantamab-lazertinib demonstrated clinically meaningful antitumor activity with no new safety signals.
Authors
- Adriano Gravina (ORCID: https://orcid.org/0000-0002-5675-8457)
- Leonardo Trani
- Giuseppe Curigliano (ORCID: https://orcid.org/0000-0003-1781-2518)
- Craig S. Meyer (ORCID: https://orcid.org/0000-0002-6655-719X)
- Shun Lu (ORCID: https://orcid.org/0000-0001-8833-7262)
- Melina E. Marmarelis (ORCID: https://orcid.org/0000-0003-2187-3583)
- Benjamin Besse (ORCID: https://orcid.org/0000-0001-5090-8189)
- Joel W. Neal (ORCID: https://orcid.org/0000-0003-3119-9334)
- Jiuwei Cui (ORCID: https://orcid.org/0000-0001-6496-7550)
- Kōichi Goto (ORCID: https://orcid.org/0000-0002-3023-2510)
- Sebastian Yves Friedrich Michels (ORCID: https://orcid.org/0000-0003-3164-870X)
- Roland E. Knoblauch
- Alexander I. Spira (ORCID: https://orcid.org/0000-0003-1303-0447)
- Pilar Garrido (ORCID: https://orcid.org/0000-0002-5899-6125)
- Isabelle Leconte (ORCID: https://orcid.org/0000-0001-7951-4204)
- Luis Paz‐Ares (ORCID: https://orcid.org/0000-0002-1947-3364)
- Frank Griesinger (ORCID: https://orcid.org/0000-0002-6822-5498)
- James Chih‐Hsin Yang (ORCID: https://orcid.org/0000-0002-5586-5138)
- Matthew A. Gubens (ORCID: https://orcid.org/0000-0002-6482-1954)
- Christina S. Baik (ORCID: https://orcid.org/0009-0007-0822-9060)
- Pascale Tomasini (ORCID: https://orcid.org/0000-0002-6474-5912)
- Mahadi Baig (ORCID: https://orcid.org/0009-0002-4456-8055)
- Minglei Zhuo (ORCID: https://orcid.org/0000-0003-2489-7791)
- Joshua Bauml (ORCID: https://orcid.org/0000-0003-4193-841X)
- Xiaorong Dong
- Levon Demirdjian (ORCID: https://orcid.org/0000-0002-1854-3658)
- Eric B. Haura (ORCID: https://orcid.org/0000-0003-3114-1909)
- Byoung Chul Cho (ORCID: https://orcid.org/0000-0002-5562-270X)
- Se‐Hoon Lee (ORCID: https://orcid.org/0000-0002-9219-3350)
- Patricia Lorenzini
- Jorge J. Nieva (ORCID: https://orcid.org/0000-0003-1605-4719)
- Gianluca Del Conte (ORCID: https://orcid.org/0000-0002-5066-5700)
- Niels Reinmuth (ORCID: https://orcid.org/0000-0002-7369-4512)
- Gee‐Chen Chang (ORCID: https://orcid.org/0000-0002-1802-417X)
- Yuki Sato (ORCID: https://orcid.org/0000-0002-7829-7524)
- Zacharias Anastasiou (ORCID: https://orcid.org/0000-0003-3813-7769)
- Marcel Wiesweg (ORCID: https://orcid.org/0000-0002-9698-9559)
- Nicolas Girard (ORCID: https://orcid.org/0000-0002-7636-6688)
- Lin Wu (ORCID: https://orcid.org/0000-0001-7078-7767)
- Enriqueta Felip (ORCID: https://orcid.org/0000-0002-7620-0098)
- Meili Sun (ORCID: https://orcid.org/0000-0002-4914-6508)
- Yongsheng Wang (ORCID: https://orcid.org/0000-0003-3673-8376)
- Yongsheng Li (ORCID: https://orcid.org/0000-0001-5621-9528)
- Yongsheng Li (ORCID: https://orcid.org/0000-0003-1914-0727)
- Jong‐Seok Lee (ORCID: https://orcid.org/0000-0001-5255-4425)
- Yiping Zhang (ORCID: https://orcid.org/0000-0002-3340-2378)
- Se Hyun Kim (ORCID: https://orcid.org/0000-0002-7154-1029)
- Sophie Cousin (ORCID: https://orcid.org/0000-0002-4847-6329)
- Youyi Zhang (ORCID: https://orcid.org/0000-0001-5186-2792)
- Joshua C. Curtin
- James Mahoney (ORCID: https://orcid.org/0009-0008-6341-0038)
- Dong-Wan Kim
- Xuesong Lyu
- Yu Yao (ORCID: https://orcid.org/0009-0002-7955-4817)
Institutions
- Hebron University (PS)
- Universitat Autònoma de Barcelona (ES)
- Centre National de la Recherche Scientifique (FR)
- Johnson & Johnson (United States) (US)
- Central South University (CN)
- Inserm (FR)
- Chongqing University (CN)
- National Taiwan University (TW)
- Yonsei University (KR)
- Jilin University (CN)
- University of Washington (US)
- Aix-Marseille Université (FR)
- Sichuan University (CN)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Johnson & Johnson (Switzerland) (CH)
- Düsseldorf University Hospital (DE)
- Fred Hutch Cancer Center (US)
- Integrated Oncology (United States) (US)
- Zhejiang Cancer Hospital (CN)
- Okayama University Hospital (JP)
- Vall d'Hebron Institut de Recerca (ES)
- Hunan Cancer Hospital (CN)
- Sichuan Cancer Hospital (CN)
- Virginia Cancer Specialists (US)
- First Hospital of Jilin University (CN)
- Vall d'Hebron Hospital Universitari (ES)
- Johnson Electric (China) (CN)
- National Cancer Center Hospital East (JP)
- University Hospital Cologne (DE)
- Chongqing Cancer Hospital (CN)
- Hôpital de la Timone (FR)
- Heinrich Heine University Düsseldorf (DE)
- University of Pennsylvania (US)
- Sungkyunkwan University (KR)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1200/jco-24-02835
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00