Integrated multi-omics analysis reveals necroptosis-related biomarker BIRC3 for early diagnosis and therapeutic targeting in preeclampsia
This comprehensive analysis implicates necroptosis in PE pathogenesis. BIRC3 is proposed as a novel diagnostic biomarker and therapeutic target, with multi-omics validation underscoring its role in immune dysregulation and placental dysfunction.
Authors
- Gengsheng Shi (ORCID: https://orcid.org/0009-0002-4263-4872)
- Peifeng Huang (ORCID: https://orcid.org/0000-0002-2129-279X)
- Qingxia Lin (ORCID: https://orcid.org/0009-0003-1004-2343)
- Yanfeng Lu
- Yu Kang (ORCID: https://orcid.org/0000-0001-5196-0376)
Institutions
- Fujian Medical University (CN)
- Quzhou City People's Hospital (CN)
- The 180th Hospital of PLA (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1371/journal.pone.0337546
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00