MCPPIR promotes cardiomyocyte proliferation and cardiac repair via o8G oxidation of POC1B mRNA
Our study reveals a previously unrecognized role of piRNAs in regulating cardiomyocyte proliferation. We demonstrate that MCPPIR drives cardiomyocyte proliferation and promotes cardiac repair in adult hearts through o8G-mediated post-transcriptional regulation of POC1B mRNA. These findings establish the MCPPIR/POC1B axis as a promising therapeutic target for ischaemic heart diseases and a novel paradigm for developing regenerative therapies against myocardial injury.
Authors
- Lu‐Yu Zhou (ORCID: https://orcid.org/0000-0002-8356-122X)
- Kaiyang Lin (ORCID: https://orcid.org/0000-0003-1421-2728)
- Yu Hui Zhang (ORCID: https://orcid.org/0009-0009-9013-9842)
- Cui-Yun Liu (ORCID: https://orcid.org/0000-0002-9591-8134)
- Hongfei Xu (ORCID: https://orcid.org/0000-0002-9293-020X)
- Yuqin Wang (ORCID: https://orcid.org/0000-0002-5008-0016)
- Xinzhe Chen (ORCID: https://orcid.org/0000-0003-1261-3552)
- Jinxi Wang (ORCID: https://orcid.org/0000-0002-7349-6153)
- Kun Wang (ORCID: https://orcid.org/0000-0002-2522-2182)
- Tao Wang (ORCID: https://orcid.org/0000-0003-1788-0166)
- Xinmin Li (ORCID: https://orcid.org/0000-0002-5544-793X)
- Jinwei Tian (ORCID: https://orcid.org/0000-0002-2730-0033)
- Meihua Zhang (ORCID: https://orcid.org/0000-0002-6821-1168)
- Sumin Yang
- Jian‐Fang Ren
Institutions
- Qingdao University (CN)
- Fujian Medical University (CN)
- Harbin Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Soochow University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Jinan Stomatological Hospital (CN)
- Fujian Provincial Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/cvr/cvaf265
- Citations
- 3
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation