Tumor and Immune Dynamics Following Sequential CDK4/6 and PD-1 Inhibition: Results from a Phase 2 Study in Dedifferentiated Liposarcoma
In this phase 2 study of palbociclib and retifanlimab, treatment led to immune-related adverse events, halting enrollment. scRNA-seq and flow cytometry revealed cell-cycle suppression, senescence, and T-cell changes. These findings highlight the rationale for this combination and the need for safer dosing strategies in larger cohorts.
Authors
- Katherine S. Panageas (ORCID: https://orcid.org/0000-0002-6591-604X)
- Matthew D. Biniakewitz (ORCID: https://orcid.org/0009-0009-9731-2337)
- Li‐Xuan Qin (ORCID: https://orcid.org/0000-0002-9367-3807)
- Viswatej Avutu (ORCID: https://orcid.org/0000-0002-2591-7187)
- Jasme Lee (ORCID: https://orcid.org/0009-0006-4492-4872)
- Ping Chi
- Phillip Wong (ORCID: https://orcid.org/0000-0002-6360-849X)
- Lauren B. Banks (ORCID: https://orcid.org/0000-0002-3443-6414)
- Rodrigo Gularte‐Mérida (ORCID: https://orcid.org/0000-0002-4383-2523)
- Damon R. Reed (ORCID: https://orcid.org/0000-0002-8238-2465)
- William D. Tap (ORCID: https://orcid.org/0000-0001-7779-2796)
- Mrinal M. Gounder (ORCID: https://orcid.org/0000-0001-8468-0119)
- Jason E. Chan (ORCID: https://orcid.org/0000-0003-0552-8544)
- Mark A. Dickson (ORCID: https://orcid.org/0000-0003-2764-751X)
- Joseph P. Erinjeri (ORCID: https://orcid.org/0000-0003-1876-727X)
- Evan Rosenbaum (ORCID: https://orcid.org/0000-0002-7499-1279)
- Andrew Koff (ORCID: https://orcid.org/0000-0003-3271-3067)
- Ronglai Shen (ORCID: https://orcid.org/0000-0001-9694-584X)
- Robert A. Lefkowitz (ORCID: https://orcid.org/0000-0003-3884-9643)
- Matthew Adamow (ORCID: https://orcid.org/0000-0002-7709-0126)
- Martina Bradić (ORCID: https://orcid.org/0000-0001-6078-5311)
- Sujana Movva (ORCID: https://orcid.org/0000-0002-6569-6606)
- Mary Louise Keohan (ORCID: https://orcid.org/0000-0002-8240-4900)
- Evan Seffar (ORCID: https://orcid.org/0000-0002-2185-5548)
- Robert G. Maki (ORCID: https://orcid.org/0000-0002-9853-2528)
- Samuel Singer (ORCID: https://orcid.org/0000-0001-9713-8230)
- Ciara M. Kelly (ORCID: https://orcid.org/0000-0002-4393-8088)
- Cristina R. Antonescu (ORCID: https://orcid.org/0000-0002-9717-8205)
- Sandra P. D’Angelo (ORCID: https://orcid.org/0000-0002-3736-3783)
- Rhoena Desir (ORCID: https://orcid.org/0009-0001-7607-1521)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0334
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00