Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs
Hyperthermia exacerbated the BrS phenotype in hiPSC-CMs carrying SCN10A and SCN5A variants, whereas LPS aggravated the phenotype in all three BrS variants through distinct mechanisms; Hyperthermia and LPS effects on BrS phenotype may be genotype-dependent.
Authors
- Xinrui Lei (ORCID: https://orcid.org/0000-0002-0627-7225)
- Nazha Hamdani (ORCID: https://orcid.org/0000-0002-3053-0008)
- Mengying Huang (ORCID: https://orcid.org/0000-0002-9719-4619)
- Alexander Moscu‐Gregor (ORCID: https://orcid.org/0000-0001-5727-8554)
- Bing Zhao (ORCID: https://orcid.org/0000-0003-0374-5449)
- Xuehui Fan (ORCID: https://orcid.org/0000-0001-9040-1155)
- Zhenxing Liao (ORCID: https://orcid.org/0000-0001-7149-8297)
- Alyssa Hohn (ORCID: https://orcid.org/0000-0001-9624-3098)
- Zenghui Meng
- Rujia Zhong (ORCID: https://orcid.org/0000-0002-6131-2660)
- Hendrik Dinkel (ORCID: https://orcid.org/0000-0001-7264-6335)
- Assem Aweimer (ORCID: https://orcid.org/0000-0002-8134-6905)
- Andreas Mügge (ORCID: https://orcid.org/0000-0001-9548-6995)
- Lasse Maywald (ORCID: https://orcid.org/0000-0001-5163-3383)
- Saltanat Zhazykbayeva
- Lukas Cyganek (ORCID: https://orcid.org/0000-0001-9120-1382)
- Ibrahim El‐Battrawy (ORCID: https://orcid.org/0000-0002-0139-1045)
- Yingrui Li (ORCID: https://orcid.org/0000-0001-6630-1277)
- Luca Schneider (ORCID: https://orcid.org/0009-0003-9612-7574)
- Mandy Kleinsorge (ORCID: https://orcid.org/0000-0001-7184-5770)
- Guoqiang Yang (ORCID: https://orcid.org/0000-0003-0473-9219)
- Alexandra Viktoria Busley (ORCID: https://orcid.org/0000-0002-5036-0093)
- Lena Rose (ORCID: https://orcid.org/0000-0002-8563-4357)
- Timo Prädel
- Yan Chen (ORCID: https://orcid.org/0000-0001-5186-7868)
- Xiaobo Zhou (ORCID: https://orcid.org/0000-0002-5895-0127)
- Feng Zhang (ORCID: https://orcid.org/0000-0001-9401-4339)
- Rui Liu
- Zhen Yang
- Qiao Lin (ORCID: https://orcid.org/0000-0002-6040-2867)
- Qiang Xu (ORCID: https://orcid.org/0000-0003-1563-579X)
- Ibrahim Akin
- Yeweynwuha Zemedi
Institutions
- Dalian Medical University (CN)
- Heidelberg University (DE)
- Southwest Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- University Medical Centre Mannheim (DE)
- Chongqing Medical University (CN)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s13287-025-04793-6
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Universitätsmedizin Göttingen
- Bundesministerium für Bildung und Forschung