Estradiol and non-REM sleep attenuate physiological and emotional responses to social-evaluative stress in healthy women
Estradiol and N3 sleep appear to independently modulate distinct facets of the response to social-evaluative stress: higher estradiol levels were associated with reduced autonomic arousal, while greater N3 sleep duration was linked to lower subjective stress. By revealing parallel pathways through which estradiol and sleep shape physiological and cognitive reactions to stress, this work contributes to a more nuanced understanding of the biological factors that may influence mental health and stress resilience.
Authors
- Christian Benedict (ORCID: https://orcid.org/0000-0002-8911-4068)
- Camilla Zetterlund
- Michaela Danek
- Diana Aline Nôga (ORCID: https://orcid.org/0000-0002-9717-7480)
- Elisa M. S. Meth (ORCID: https://orcid.org/0000-0003-4232-8242)
- Viviana Rossi
- André P. Pacheco (ORCID: https://orcid.org/0000-0003-2523-1502)
- Pei Xue (ORCID: https://orcid.org/0000-0002-0364-2936)
- Per Simonsson
- Samira F. M. Noory
- Céline Heel
- Frank Wedzinga
- Abdullah Almajni
Institutions
- Uppsala University (SE)
- Oslo University Hospital (NO)
- University of Oslo (NO)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12916-025-04508-x
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00